HGH (Somatropin) Lyophilized Powder

Overview

Human Growth Hormone (HGH; Somatropin; CAS 12629-01-5) is a 191-amino acid single-chain polypeptide secreted by somatotroph cells of the anterior pituitary gland. Vitaconin supplies recombinant HGH produced via recombinant DNA technology, yielding a sequence and three-dimensional structure identical to endogenous human growth hormone. Unlike short synthetic peptides produced by solid-phase synthesis, recombinant HGH is expressed in host cell systems (typically E. coli or mammalian expression systems), then purified to pharmaceutical research grade through multi-step chromatographic processes. The resulting lyophilized product maintains full biological activity and is suitable for use in a wide range of research applications including metabolic studies, body composition research, growth hormone deficiency models, and anti-aging biology.

Technical Specifications

Key Research Findings

The landmark Rudman et al. study published in the New England Journal of Medicine in 1990 established the foundational clinical evidence base for HGH in body composition research, demonstrating significant increases in lean body mass and reductions in adipose tissue in men over 60 with low IGF-1 levels receiving recombinant growth hormone over six months [1]. This study, while frequently cited in both clinical and research contexts, generated extensive follow-up investigation into GH’s role in metabolic regulation, muscle protein synthesis, and adipolysis — providing the scientific framework that continues to guide HGH research programs globally.

A systematic review of 31 randomized controlled trials by Liu et al. (2007) in Annals of Internal Medicine evaluated the safety and efficacy profile of HGH across healthy elderly populations, documenting dose-dependent effects on body composition alongside a well-characterized adverse event profile — data that remains central to research institutions designing HGH study protocols [2]. For compounding pharmacies and research institutions working with HGH, understanding both the efficacy signals and the safety literature is essential for protocol design and regulatory compliance in applicable jurisdictions.

Why Purity Matters

At 22 kDa, recombinant HGH is substantially larger than synthetic peptides, making it more susceptible to aggregation, oxidative degradation, and host cell protein (HCP) contamination from the expression system. These impurities can elicit immunogenic responses in animal research models, confound dose-response data, or reduce specific biological activity below specifications. SE-HPLC (size-exclusion HPLC) purity analysis is the industry standard for recombinant protein quantification — confirming monomeric content and detecting aggregated or degraded species. For research institutions and manufacturers requiring supplier documentation for study protocols or regulatory submissions, batch-verified purity at ≥99.9% with full MS identity confirmation provides the analytical baseline required for reliable data generation.

References:
[1] Rudman D, et al. Effects of Human Growth Hormone in Men over 60 Years Old. N Engl J Med. 1990;323(1):1–6. PMID: 2355952
[2] Liu H, et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007;146(2):104–15. PMID: 17227934

Quality & Documentation

Each batch of HGH raw material is individually tested before shipment. Included with every order:

• HPLC purity verification (≥99.9%)
• Mass spectrometry (MS) identity confirmation
• Batch number for full traceability

COA available upon request before order commitment.

Q: Is HGH available in liquid formulation?
Yes, liquid formulation is available on request. Please specify your preferred concentration and solvent when inquiring. Note that reconstituted HGH has a shorter shelf life than lyophilized powder and requires refrigeration at 2–8°C.

Q: How should HGH raw material be stored?
Store unreconstituted lyophilized HGH at −20°C, sealed, away from light and moisture. Shelf life is 24 months under proper conditions. Once reconstituted, store at 2–8°C and use within the timeframe specified in the COA.

Q: What is the difference between HGH and HGH fragment peptides such as AOD-9604?
HGH (Somatropin, CAS 12629-01-5) is the full 191-amino acid recombinant protein, activating the full spectrum of GH receptor-mediated pathways. AOD-9604 is a synthetic fragment of the HGH C-terminus (amino acids 176–191), studied specifically for adipolytic activity with a different receptor binding profile. Both are available from Vitaconin with individual COA documentation.